Acute asthma attacks trigger the TRPV1 receptor* in the carotid bodies that control breathing.
1. An acute asthma attack leads to an increase in systemic levels of LPA (lysophosphatidic acid) and other inflammatory mediators.
2. LPA and other inflammatory mediators activate the TRPV1 receptor* in the carotid bodies (clusters of neurons in the neck that control breathing).
3. Neurons from the carotid bodies send the information to the brain cardiorespiratory center.
4. Vagus nerve simulations trigger bronchoconstriction (narrowing of the airways).